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Rift Valley fever (RVF) virus is associated with recurring disease epidemics among livestock and humans in sub-Saharan Africa and Middle East, where the virus is endemic in certain ecosystems. Since the mechanisms of its maintenance during the long (4–10 year) inter-epidemic periods (IEPs) are poorly understood, we reviewed the latest findings that shed light on this, and identify ecological factors unique to the endemic areas.

Rift Valley Fever Virus—How and Where Virus Is Maintained During Inter-epidemic Periods