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We would like to thank Professor Parsons for his interest and comments concerning our manuscript “Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach” [1]. We totally agree with Parsons that the choice of appropriate cell model is of paramount importance in in vitro drug toxicity testing [2]. Moreover, using at least two cell lines and two toxicity assays is endorsed in order to have more accurate and relevant interpretation of drug toxicity for clinical use. In our study, we have used the SH-SY5Y and NSC-34 cell lines, and 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and resazurin reduction assays, all of which are commonly used for assessing the toxicity of different compounds. In the present study, the toxicity of both compounds, oxycodone and morphine, appeared to be similar in both cell lines and both assays.

Author’s Reply to Parsons: “Cytotoxicity of Oxycodone and Morphine in Human Neuroblastoma and Mouse Motoneuronal Cells: A Comparative Approach”