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Developing countries, particularly those with a rapid development, are experiencing increasing pollution by sulfur dioxide (SO 2 ). Despite the considerable SO 2 exposure effect on health, there is little evidence regarding this fact in Iran, as one of the largest oil and gas producing countries in the world. The present study, therefore, was designed to investigate the burden of cardiovascular and respiratory diseases attributed to the SO 2 exposure in Iran, over a 26-year period.

The burden of cardiovascular and respiratory diseases attributed to ambient sulfur dioxide over 26 years