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Two new sesquiterpenoids, artemlavanins A ( 1 ) and B ( 3 ), together with fifteen known compounds ( 2  and  4−17 ) were isolated from the EtOH extract of  Artemisia lavandulaefolia . The structures of new compounds were elucidated by extensive spectroscopic analyses (HRESIMS, 1D and 2D NMR) and ECD calculations. Compound  1  was a sesquiterpenoid lactone possessing a rearranged eudesmane skeleton; compounds  2–5 ,  6–8 ,  9  and  10–12  belonged to the eudesmane, guaiane, oppositane and farnesane sesquiterpenoids, respectively; compounds  13–17  were the phenyl derivatives with a 4-hydroxyacetophenone moiety. Twelve compounds ( 1–3 ,  5–7 ,  10–12 ,  14 ,  15  and  17 ) displayed cytotoxicity against hepatic stellate cell line LX2 (HSC-LX2) with IC 50  values ranging from 35.1 to 370.3  μ M. Compounds  2 ,  7 ,  10–12  and  17  exhibited the stronger cytotoxicity than silybin (IC 50 , 169.6  μ M) with IC 50  values of 82.1, 35.1, 95.0, 83.8, 81.6 and 90.1  μ M. Compound  7  as the most active one showed significant inhibition on the deposition of human collagen type I (Col I), human hyaluronic acid (HA) and human laminin (HL) with IC 50  values of 10.7, 24.5 and 13.3  μ M.    Graphic AbstractElectronic supplementary material  The online version of this article (10.1007/s13659-020-00254-0) contains supplementary material, which is available to authorized users.

Artemlavanins A and B from Artemisia lavandulaefolia and Their Cytotoxicity Against Hepatic Stellate Cell Line LX2