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Three new amide alkaloids piperlongumamides A-C ( 1–3 ), together with 12 known ones ( 4–15 ), were isolated from the fruits of  Piper longum . The structures of the new isolates were determined using spectroscopic data analyses. Cytotoxic activity of these amides against HL-60 (human leukemia), A-549 (human lung cancer), MCF-7 (human breast cancer), SMMC-7721 (human liver cancer) and SW480 (human rectal cancer) cell lines were evaluated. Piperchabamide B ( 11 ) exhibited weak inhibitory activity against HL-60 (IC 50  = 21.32 μM ), A-549 (IC 50  = 23.82 μM ) and MCF-7 (IC 50  = 16.58 μM ) cell lines.Electronic Supplementary Material  Supplementary material is available for this article at 10.1007/s13659-013-0073-0 and is accessible for authorized users.

New amide alkaloids from Piper longum fruits