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The therapeutic drug-loaded nanoparticles (NPs, 20-100 nm) have been widely used to treat brain disorders. To improve systemic brain delivery efficacy of these NPs, it is necessary to quantify their transport parameters across the blood-brain barrier (BBB) and understand the underlying transport mechanism.

Transcellular Model for Neutral and Charged Nanoparticles Across an In Vitro Blood–Brain Barrier