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The standard MR Dixon-based attenuation correction (AC) method in positron emission tomography/magnetic resonance (PET/MR) imaging segments only the air, lung, fat and soft-tissues (4-class), thus neglecting the highly attenuating bone tissues and affecting quantification in bones and adjacent vessels. We sought to address this limitation by utilizing the distinctively high bone uptake rate constant K i expected from 18 F-Sodium Fluoride ( 18 F-NaF) to segment bones from PET data and support 5-class hybrid PET/MR-driven AC for 18 F-NaF and 18 F-Fluorodeoxyglucose ( 18 F-FDG) PET/MR cardiovascular imaging.

Hybrid PET- and MR-driven attenuation correction for enhanced 18F-NaF and 18F-FDG quantification in cardiovascular PET/MR imaging