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Currently, there is no established non-invasive imaging approach to directly evaluate myocardial microcirculatory function in order to diagnose microvascular disease independent of co-existing epicardial disease. In this work, we developed a methodological framework for quantification of intramyocardial blood volume (IMBV) as a novel index of microcirculatory function with SPECT/CT imaging of 99m Tc-labeled red blood cells (RBCs).

Quantification of intramyocardial blood volume with 99mTc-RBC SPECT-CT imaging: A preclinical study