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the suboptimalphysical characteristics of the historical agent Tl-201have prompted the development of Tc-99 m-labeledmyocardial perfusion imaging agents with more favor-able emission energy and dosimetry. For a number ofreasons that were addressed in the abovementionededitorial, and despite excellent myocardial extractionand encouraging clinical results, the neutral and lipo-philic tracers TcN-NOET and Tc-TEBOROXIME havenot reached routine clinical use.

Novel SPECT perfusion imaging agents with improved myocardial or liver kinetics: Experimental studies and the need for clinical evaluation