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Alkylating agents used in chemotherapy are mutagenic and have strong leukemogenic potential. The most serious long term complication of chemotherapy is the development of secondary disease, particularly hematological malignancy; they have rarely been reported in the context of ovarian cancer treatment. We describe quite a rare occurrence of a myelodyplastic/myeloproliferative neoplasm, unclassified (MDS/MPN-U) with acute leukemic transformation and multiple cytogenetic abnormalities not usually found together as JAK2 V617F mutation, 5q- and 7q-deletion, after exposure to paclitaxel and carboplatin based chemotherapy in a patient treated for ovarian cancer. We should be aware of such complication whose prognosis is really poor.

indian journal of hematology and blood transfusion/indian journal of hematology and blood transfusion

Therapy Related Myelodysplasia/Myeloproliferative Neoplasia-Unclassified with Acute Leukemic Transformation Following Paclitaxel and Carboplatin Based Chemotherapy in an Ovarian Cancer Patient