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Rh antigen is a widely studied but not already known antigen. RH48 (JAL) is a low-incidence Rh antigen of unknown molecular background and is proposed for association with weakened expression of RhCE antigens. Here, the author performed a bioinformatics approach to study the probability of JAL mutation. It can be shown that JAL is a highly unstable molecule that is prone for mutation.

Mutation in Rh48: Assessment for possible mutation prone point