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During development, there are restricted time windows (critical periods) in which the juvenile brain is particularly plastic and gets optimized in an activity-dependent way. The balance between two signalling scaffold proteins of excitatory synapses with opposing functions is essential for both synapse maturation and the timing of critical periods. We hope that our new results will help to develop strategies for rehabilitation after brain lesions and for treating neurodevelopmental disorders.

Yin und Yang beim Lernen im jungen Gehirn: Balance von PSD-95 und PSD-93