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Dear Editors,We read with interest the paper ‘‘Capsaicin receptors arecolocalized with sweet/bitter receptors in the taste sensingcells of circumvallate papillae’’ published by Moon et al.[1]. The authors report a double reaction of T1R2-, T1R3-or T2R6 positive vallate cells with anti-VR1 antibodies ofrat circumvallate papillae. They also found that about 60%of VR1 positive cells in the circumvallatae papillae reac-tive with a-gustducin. The authors concluded that capsaicinmay interact with transducin pathways of sweet and bittersensations.Many researchers described the suppressive effects ofcapsaicin on responses to taste stimuli of sweet, bitter, andumami in humans [2–4]. At lower concentrations, capsai-cin can also elicit bitter [4, 5], and sweet sensations [5].Green and Schullery described bitter sensations whencapsaicin was applied to fungiform, foliate, and circum-vallate papillae of the human tongue [4].In our study, capsaicin was applied to the dorsal anteriortongue in healthy subjects. Beside bitter, sour and saltysensations, capsaicin elicited also sweet sensations [5].The presented study reported evidence of VR1 receptorsin taste cells in circumvallate papillae in rats. Based on theauthor’s ndings, one might speculate that VR1 receptorscan also be found in taste cells of the fungiform papillae ofthe dorsal anterior tongue even in humans. This mayexplain why some healthy subjects report sweet sensationsafter stimulation with capsaicin at low concentrations.Knowledge of the VR1 receptors of taste cells of fungiformpapillae may also help to explain symptoms after chordatympani nerve (CTN) transection. In patients with tran-sected CTN the capsaicin thresholds were lower at theipsilateral tongue side compared to the contralateral side[6].We would like to congratulate the authors for theirexcellent study because they clearly emphasize the need forfurther research in taste-trigeminal interactions.References

In reference to capsaicin receptors are colocalized with sweet/bitter receptors in the taste sensing cells of circumvallate papillae