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Peripheral T-cell lymphomas (PTCLs) are heterogeneous neoplasms of mature T cells and represent 10-15 % of all lymphoid malignancies. In the 1970s, when it was first realized that non-Hodgkin lymphoma cells were derived from either T cells, B cells, or NK cells, T-cell lymphomas were recognized as a separate clinicopathological entity of lymphoid malignancies. Although various methodologies for the classification of lymphomas have been developed, PTCLs have been often regarded as ''orphan diseases'', reflecting the difficulties encountered in their classification, diagnosis, and treatment.

Guest Editorial: peripheral T-cell lymphomas: progress is not “peripheral”, but “central”