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[[Formula: see text]] N-isopropyl-p-iodoamphetamine ([Formula: see text]-IMP) is an ideal perfusion tracer for single photon emission computed tomography, which shows good linearity between cerebral blood flow (CBF) and accumulation. However, quantification of CBF using [Formula: see text]-IMP without arterial blood sampling has been challenging, with previous methods requiring empirically obtained regression formulae to estimate CBF. Furthermore, the CBF value obtained via some of the previous methods would be affected by the clearance rate of [Formula: see text]-IMP from the lungs. This paper introduces a new non-invasive quantification method for CBF using [Formula: see text]-IMP and dynamic planar images.

A new non-invasive graphical method for quantification of cerebral blood flow with[ $$^{123}\hbox {I}$$ 123 I ] IMP