Open AccessA network map of IL‐33 signaling pathway
Author(s) -
Pinto Sneha M.,
Subbannayya Yashwanth,
Rex D. A. B.,
Raju Rajesh,
Chatterjee Oishi,
Advani Jayshree,
Radhakrishnan Aneesha,
Keshava Prasad T. S.,
Wani Mohan R.,
Pandey Akhilesh
Publication year - 2018
Publication title -
journal of cell communication and signaling
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 44
eISSN - 1873-961X
pISSN - 1873-9601
DOI - 10.1007/s12079-018-0464-4
Subject(s) - signal transduction , proinflammatory cytokine , pi3k/akt/mtor pathway , immunology , phosphorylation , medicine , cytokine , biology , inflammation , cancer research , microbiology and biotechnology
Abstract Interleukin‐33 (IL‐33) is a member of the IL‐1 family of cytokines that play a central role in the regulation of immune responses. Its release from epithelial and endothelial cells is mediated by pro‐inflammatory cytokines, cell damage and by recognition of pathogen‐associated molecular patterns (PAMPs). The activity of IL‐33 is mediated by binding to the IL‐33 receptor complex (IL‐33R) and activation of NF‐κB signaling via the classical MyD88/IRAK/TRAF6 module. IL‐33 also induces the phosphorylation and activation of ERK1/2, JNK, p38 and PI3K/AKT signaling modules resulting in the production and release of pro‐inflammatory cytokines. Aberrant signaling by IL‐33 has been implicated in the pathogenesis of several acute and chronic inflammatory diseases, including asthma, atopic dermatitis, rheumatoid arthritis and ulcerative colitis among others. Considering the biomedical importance of IL‐33, we developed a pathway resource of signaling events mediated by IL‐33/IL‐33R in this study. Using data mined from the published literature, we describe an integrated pathway reaction map of IL‐33/IL‐33R consisting of 681 proteins and 765 reactions. These include information pertaining to 19 physical interaction events, 740 enzyme catalysis events, 6 protein translocation events, 4 activation/inhibition events, 9 transcriptional regulators and 2492 gene regulation events. The pathway map is publicly available through NetPath ( http://www.netpath.org /), a resource of human signaling pathways developed previously by our group. This resource will provide a platform to the scientific community in facilitating identification of novel therapeutic targets for diseases associated with dysregulated IL‐33 signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_120 .