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A simple, mild and convenient method has been developed for the synthesis of 3,4,5-trialkyl-1,3-thiazole-2(3H)-thione derivatives through one pot three-component reaction between a primary amine, carbon disulphide, and α-haloketone in the presence of potassium iodide at room temperature conditions. The products were obtained with excellent yield and appropriate reaction times. This reaction represents a rapid and unprecedented route to the described molecules that have biological specifications.

The reaction of carbon disulphide with α-haloketones and primary amines in the presence of potassium iodide as catalyst