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It is a pleasure to present this special issue of IJCARS that contains several of the best papers that were submitted to the 19th International Conference onMedical Image Computing and Computer-Assisted Intervention (MICCAI 2016) which was held in Athens, Greece. MICCAI 2016 was organized in a collaboration among University College London, Harvard Medical School, the Hebrew University of Jerusalem, and Bogazici, Sabanci, and Istanbul Technical Universities.

Guest editorial of the IJCARS MICCAI 2016 special issue