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The impact of efflux transporters in intracellular concentrations of a drug can be predicted with modeling techniques. In Part 1, several compartmental models were developed and evaluated. The goal of Part 2 was to apply these models to the characterization and interpretation of saturation kinetic data.

Compartmental Models for Apical Efflux by P-glycoprotein: Part 2—A Theoretical Study on Transporter Kinetic Parameters