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Glutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual genetic makeup. Therefore, the identification of alleles and genotypes in these genes within a population may help to better design genetic susceptibility and pharmacogenetic studies. We performed the present study to establish the frequencies of the  GSTM1 ,  GSTT1 , and  GSTP1  c. 313A &gt; G (rs1695) polymorphisms in 206 individuals of the Malian healthy population.  GSTM1  and  GSTT1  were genotyped by using multiplex polymerase chain reaction, whereas genotypes of  GSTP1  were identified by polymerase chain reaction followed by restriction fragment length polymorphism. The frequencies of  GSTM1 -null and  GSTT1 -null genotypes were respectively 24.3 and 41.3%. The observed genotype frequencies for  GSTP1  were 25.73% homozygous wild-type AA, 49.03% heterozygous AG and 25.24% homozygous mutant GG. The frequency of  GSTP1 -A allele was 50.24% versus 49.76% for  the GSTP1 - G allele . The distribution of these three genes was homogeneous between men and women (p &gt; 0.05). We found no statistical association between the presence of a particular profile of  GSTM1  or  GSTT1  with the genotypes of  GSTP1 ( p &gt; 0.05). Nevertheless, we noticed that the majority of the individuals harboring the  GSTM1 -present or the  GSTT1 -present harbor also the  GSTP1 -AG genotype. In addition, the triple genotype  GSTM1 -present/ GSTT1 -present/AG was the most frequent with 25.2%. Our findings will facilitate future studies regarding genetic associations of multifactorial diseases and pharmacogenetic, thus opening the way to personalized medicine in our population.

Genetic polymorphism of drug metabolism enzymes (GSTM1, GSTT1 and GSTP1) in the healthy Malian population