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Several errors and shortcomings in the paper by Liu et al. (J. Solution Chem. 45:932–946, 2016) concerning the calculation of Abraham model solution descriptors of telmisartan are discussed. The authors’ calculated solute descriptors give an unreasonable value for the water to 1-octanol partition coefficient of telmisartan, which is eight orders of magnitude smaller than values predicted by other methods. The correct computation methodology for determining solute descriptors from experimental solubility data is presented.

Commentary on “Measurement and Correlation of the Solubility of Telmisartan (Form A) in Nine Different Solvents from 277.85 to 338.35 K”