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With great interest, we read the recent article entitled "Association between BRIP1 (BACH1) polymorphisms and breast cancer risk: a meta-analysis" published online in Pabalan et al. (Breast Cancer Res Treat 137:553-558, 2013). This article suggests that overall summary estimates imply no associations but suggest susceptibility among carriers of the C47G polymorphism and Pro-Ser genotype in premenopausal women. The result is encouraging. Nevertheless, several key issues in this meta-analysis are worth noticing.

Note of clarification of data in the paper entitled association between BRIP1 (BACH1) polymorphisms and breast cancer risk