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We describe a contactless optical technique selectively enhancing superficial blood vessels below variously pigmented intact human skin by combining images in different spectral bands. Two CMOS-cameras, with apochromatic lenses and dual-band LED-arrays, simultaneously streamed Left (L) and Right (R) image data to a dual-processor PC. Both cameras captured color images within the visible range (VIS, 400-780 nm) and grey-scale images within the near infrared range (NIR, 910-920 nm) by sequentially switching between LED-array emission bands. Image-size-settings of 1280 x 1024 for VIS &amp; 640 x 512 for NIR produced 12 cycles/s (1 cycle = 1 VIS L&amp;R-pair + 1 NIR L&amp;R-pair). Decreasing image-size-settings (640 x 512 for VIS and 320 x 256 for NIR) increased camera-speed to 25 cycles/s. Contrasts from below the tissue surface were algorithmically distinguished from surface shadows, reflections, etc. Thus blood vessels were selectively enhanced and back-projected into the stereoscopic VIS-color-image using either a 3D-display or conventional shutter glasses. As a first usability reconnaissance we applied this custom-built mobile stereoscopic camera for several clinical settings:* blood withdrawal;* vein inspection in dark skin;* vein detection through iodide;* varicose vein and nevi pigmentosum inspection. Our technique improves blood vessel visualization compared to the naked eye, and supports depth perception.

Remote Non-invasive Stereoscopic Imaging of Blood Vessels: First In-vivo Results of a New Multispectral Contrast Enhancement Technology