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19 F MRI requires biocompatible and non-toxic soluble contrast agents with high fluorine content and with suitable 19 F relaxation times. Probes based on a DOTP chelate with 12 magnetically equivalent fluorine atoms (DOTP-tfe) and a lanthanide(III) ion shortening the relaxation times were prepared and tested.

Low-molecular-weight paramagnetic 19F contrast agents for fluorine magnetic resonance imaging