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The effects of optimized slowly digestible starch (SDS) and resistant starch (RS) from rice starch on weight gain and lipid metabolism in mice (C57BL/6J mice) fed a high-fat diet were investigated. The optimum conditions for SDS were obtained at the pullulanse concentration ( X  1 ) of 498 μL, storage temperature) ( X  2 ) of 47°C, and A/C cycle ( X  3 ) of 5, and for RS, were determined to be 838 μL ( X  1 ), 62°C ( X  2 ), and a cycle of 3 ( X  3 ) using response surface methodology (RSM). Mice fed SDS and RS for 6 weeks showed both significantly decreased weight gain and fat pad weight ( p &lt;0.05). Significant decrease in total lipid, triglyceride, and cholesterol concentrations in serum and liver was observed in both SDS and RS group compared to HFD groups ( p &lt;0.05). Although both of intake SDS and RS significantly contributed to beneficial effects, RS groups was more effective than SDS group in all parameters.

Comparative effects of slowly digestible and resistant starch from rice in high-fat diet-induced obese mice