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There are conflicting studies on the influence of fractionated preoperative 5 days of 5 Gy irradiation on tissue oxygenation and subsequent colonic anastomotic strength. To elucidate the effect of preoperative irradiation on anastomotic strength, an isolated colon loop model was developed.

Preoperative irradiation with 5 × 5 Gy in a murine isolated colon loop model does not cause anastomotic weakening after colon resection