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Angiogenesis is a driver of platinum resistance in ovarian cancer. We assessed the effect of combination pazopanib and paclitaxel followed by maintenance pazopanib in patients with platinum-resistant/refractory ovarian cancer. Integrins α v β 3 and α v β 5 are both upregulated in tumor-associated vasculature. [ 18 F]Fluciclatide is a novel PET tracer that has high affinity for integrins α v β 3/5 , and was used to assess the anti-angiogenic effect of pazopanib.

[18F]Fluciclatide PET as a biomarker of response to combination therapy of pazopanib and paclitaxel in platinum-resistant/refractory ovarian cancer