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Nicotine use in schizophrenia has traditionally been explained as "self-medication" of cognitive and/or nicotinic acetylcholinergic receptor (nAChR) abnormalities.

psychopharmacology/psychopharmacologia

Nicotine effects in adolescence and adulthood on cognition and α4β2-nicotinic receptors in the neonatal ventral hippocampal lesion rat model of schizophrenia