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Salvinorin A, the primary psychoactive derivative of the hallucinogenic herb Salvia divinorum, is a potent and highly selective kappa-opioid receptor (KOR) agonist. Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects.

Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents