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Every year, the editors of the Archives of Toxicology review the most cited articles from the previous 2 years (Table 1). This year, topping the most cited list (51 citations) is a comprehensive review by Arthur I. Cederbaum on the mechanisms of ethanol-induced liver injury, describing the contributions of oxidative stress and CYP2E1. The second most cited article also focuses on oxidative stress, but from a different perspective. Chung S. Yang describes how polyphenolic compounds in tea act as anticarcinogens. Besides their antioxidant properties, polyphenolic compounds prevent DNA damage and modulate carcinogen metabolism. Metabolic detoxification of carcinogens is also catalyzed by epoxide hydrolases. Martina Decker and colleagues contributed a comprehensive review, in which they describe that epoxide hydrolases play a role not only in detoxification but also in signaling processes by metabolizing lipids, thereby influencing blood pressure and inflammation. Edward J. Calabrese critically discusses why the hormesis model became marginalized in dose–response modeling. Finally, the most frequently cited original article was published by Hasan Mahmud and colleagues. They show that arsenic induces suicidal death of erythrocytes by increasing cytosolic Ca concentrations, which may explain why environmental arsenic exposure causes anemia. Table 1 provides highlights of the most cited articles of 2009 and 2010. References

archives of toxicology

Most cited articles: ethanol-induced hepatotoxicity, anticarcinogenic effects of polyphenolic compounds in tea, dose–response modeling, novel roles of epoxide hydrolases and arsenic-induced suicidal erythrocyte death