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The blood triacylglycerol level is one of the main determinants of blood Mg 2+ concentration in individuals with type 2 diabetes. Hypomagnesaemia (blood Mg 2+ concentration &lt;0.7 mmol/l) has serious consequences as it increases the risk of developing type 2 diabetes and accelerates progression of the disease. This study aimed to determine the mechanism by which triacylglycerol levels affect blood Mg 2+ concentrations.

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+