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disease in which increased uncoupling protein-2 has been documented [4, 5], phosphoenolpyruvate carboxykinase is found to be reduced [6], seemingly ruling out a straight-forward relation between uncoupling protein-2 and gluconeogenesis even in a mildly diabetic animal such as the obese mouse. As the author, himself, acknowledges it has yet to be proven that the proposed cascade of events does in fact occur and we await with much interest the findings of those studies.

diabetologia

Circulating ghrelin concentrations are reduced in healthy offspring of Type 2 diabetic subjects, and are increased in women independent of a family history of Type 2 diabetes