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Abstract  Wild-type TP53 plays an important role in the regulation of immune response and systemic inflammation. In type 1 diabetes (T1D),  TP53  pathways are upregulated and an increased susceptibility to apoptosis is observed. We hypothesize that  TP53  codon 72 polymorphism could be associated with complications and comorbidities in patients with T1D. We have investigated the associations of the  TP53  codon 72 polymorphism with the T1D complications and comorbidities (retinopathy, nephropathy, hypertension, dyslipidemia, autoimmune thyroiditis, and celiac disease) in 350 patients. The key results of our approach are as follows: (1) In diabetic subjects, the Pro/Pro genotype is associated with an increased risk of microvascular complications, dyslipidemia, and celiac disease; (2) the Arg/Arg variant is associated with a decreased risk of autoimmune thyroiditis and celiac disease; (3) the Pro allele is associated with an increased risk of dyslipidemia, autoimmune thyroiditis, and celiac disease. Although further studies are required, our results for the first time indicate that the  TP53  codon 72 polymorphism could be considered a genetic marker to predict the increased susceptibility to some T1D complications and comorbidities.    Key messagesWe analyzed the  TP53  codon 72 polymorphism in patients with T1D.    Pro/Pro genotype is associated with an increased risk of microvascular complications, dyslipidemia, and celiac disease.    The Arg/Arg variant is associated with a decreased risk of autoimmune thyroiditis and celiac disease.    The Pro allele is associated with an increased risk of dyslipidemia, autoimmune thyroiditis, and celiac disease.

Associations of TP53 codon 72 polymorphism with complications and comorbidities in patients with type 1 diabetes