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In the reduction of 4d dualities to 3d there are non-perturbative effectsarising from monopoles acting as instantons. This mechanism has been reproducedin string theory by engineering the theories in a IIA brane setup. Neverthelessthere are limiting cases of the 4d dualities where the dual theories areactually confined phases of the UV gauge theories. In these cases the monopolesare absent and the mechanism of reduction of the 4d duality has to be modified.In this paper we investigate such modification in the brane setup. The mainobservation behind our analysis is that in the 4d case the superpotential ofthe confined theories can been obtained also as the "exotic" contribution of aD0 brane, a stringy instanton. When considering these configurations wereproduce the field theory results in the brane setup. We study both theunitary and the symplectic case. As a further check we study the reduction ofthe 4d superconformal index to the 3d partition function for these theories.

4d/3d reduction of s-confining theories: the role of the "exotic" D instantons