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The LHC sensitivity to an anomalous Higgs coupling to the top quark in theHiggs-top associated production is analyzed. Thanks to the strong destructiveinterference in the t-channel for standard model couplings, this process can bevery sensitive to both the magnitude and the sign of a nonstandard top-Higgscoupling. We analyze cross sections and the main irreducible backgrounds forthe $H \to \gamma \gamma$ decay channel. Sensitivities to an anomalous sign forthe top Yukawa coupling are found to be large. In particular, at \sqrt{s}=14TeV, assuming a universal rescaling in the Yukawa sector, a parton-levelanalysis with realistic selection cuts gives a signal-to-background ratio S/B ~5, for -1.5 < Y_t/Y_t^{SM} < 0. A number of events S ~ 10 (with correspondingsignificances ~ 3 \sigma) are expected for 60 fb^{-1}, to be compared with thestandard-model expectation S ~ 0.3.

Single top and Higgs associated production as a probe of the Htt coupling sign at the LHC