English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The hypothalamic pituitary adrenal (HPA) axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's cortisol level. Dysregulation of the HPA axis is implicated in numerous stress-related diseases. For a structured model of the HPA axis that includes the glucocorticoid receptor but does not take into account the system response delay, we analyze linear and non-linear stability of stationary solutions. For a second mathematical model that describes the mechanism of the HPA axis self-regulatory activities and takes into account a delay of system response, we prove existence of periodic solutions under certain assumptions on ranges of parameter values and analyze stability of these solutions with respect to the time delay value.

Existence and Stability Analysis of Solutions for an Ultradian Glucocorticoid Rhythmicity and Acute Stress Model