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In this paper, cost functions are tested for 2D registration of portal and reference images for treatment verification in radiotherapy. Tests were performed with and without pre-processing for 96 image pairs of various treatment sites. The best results were obtained when the images were preprocessed by unsharp masking and histogram equalization. This led to a success rate of about 88% and a difference with clinical registration of 1.2 mm SD and 1 degree SD for most of the tested cost functions. The number of local minima with mutual information is much larger than with the other tested cost functions.

Evaluation of Cost Functions for Gray Value Matching of 2D Images in Radiotherapy