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Volume registration, by means of minimizing rms pixel value differences, was tested on pairs of pelvic CT scans in a perturbation experiment to determine its robustness. The tests included registration of 9 scans to themselves and registration of 17 clinical image pairs. Local image artifacts have no influence on performance, but global distortions and organ movement severely degraded the reproducibility. By limiting the algorithm to the gray value range of bone the accuracy is improved at the cost of reliability.

The Effect of Organ Motion and Image Artifacts on Monomodal Volume Registration