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Hyperthermic isolated limb perfusion (HILP) with tumor necrosis factor alpha (TNF-alpha), interferon gamma, and melphalan has proved to be useful in the treatment of recurrent malignant melanoma and of locally advanced soft tissue sarcomas of the extremities.

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Hyperthermic Isolated Limb Perfusion With Tumor Necrosis Factor α, Interferon Gamma, and Melphalan for Locally Advanced Nonmelanoma Skin Tumors of the Extremities